ea0099p419 | Adrenal and Cardiovascular Endocrinology | ECE2024
Mir-Bashiri Sanas
, Tetti Martina
, Froebel Dennis
, Reiss Dunja
, Bechmann Nicole
, Peitzsch Mirko
, Eisenhofer Graeme
, Reincke Martin
, Williams Tracy Ann
Background: Primary aldosteronism (PA) is the most frequent cause of endocrine hypertension associated with excess aldosterone production from one or both adrenal glands. Somatic or germline mutations in the KCNJ5 potassium channel cause an imbalance in intracellular ion homeostasis. This ultimately drives aldosterone overproduction in some sporadic forms of PA and a familial form of the disease (familial hyperaldosteronism type 3). Our objective was to identify small molecule...